Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 19/20 | 0.60 |
| ▸ | CA2 | P00918 | 19/20 | 0.60 |
| ▸ | CA9 | Q16790 | 5/20 | 0.58 |
| ▸ | CA12 | O43570 | 3/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
| ▸ | CA5A | P35218 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2429469 | 0.96 | CA1 (0.57) | CA1CA2CA9CA12CA6 | |
| SCHEMBL6118940 | 0.85 | CA1 (0.69) | CA1CA2CA9CA12CA6 | |
| SCHEMBL4463532 | 0.78 | CA1 (0.70) | CA1CA2CA9CA12CA6 | |
| SCHEMBL31309573 | 0.78 | CA1 (0.70) | CA1CA2CA9CA12CA6 | |
| SCHEMBL2002382 | 0.77 | GAA (0.50) | — | |
| SCHEMBL3694286 | 0.76 | CA2 (0.67) | CA1CA2CA9CA12CA6 | |
| SCHEMBL5176819 | 0.76 | CA1 (0.57) | CA1CA2CA9CA12CA6 | |
| SCHEMBL11760578 | 0.76 | GAA (0.61) | — | |
| SCHEMBL7633149 | 0.75 | CA2 (0.65) | CA1CA2CA9CA12CA6 | |
| SCHEMBL6226263 | 0.75 | CA1 (0.75) | CA1CA2CA9CA12CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018381-A2 | USE OF 2-(PURIN-9-YL)-TETRAHYDOFURAN-3,4-DIOL DERIVATIVES AS ADENOSINE A2A RECEPTOR AGONISTS | Novartis AG (CH) | 2009-01-28 | — | — | EP | claimed |
| WO-2007121918-A2 | USE OF 2-(PURIN-9-YL)-TETRAHYDOFURAN-3,4-DIOL DERIVATIVES AS ADENOSINE A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2007-11-01 | — | — | WO | claimed |
| CN-1370163-A | Imidazo [1,2-A] pyridine and pyrazolo [2,3-a] pyridine derivatives | ASTRAZENECA AB (SE) | 2002-09-18 | — | — | CN | disclosed |