SCHEMBL3980048

SCHEMBL3980048

COc1cccc(C(=O)NC2CC3CC[C@@H](C2)N3c2ccc(C(=O)NCCc3ccccc3)cn2)c1C

nearest known ligand 0.87

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 13/20 0.87
HSP90AB1 P08238 13/20 0.87
NPC1 O15118 2/20 0.51
ALDH1A1 P00352 2/20 0.51
MAPT P10636 2/20 0.51
RAB9A P51151 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
LMNA P02545 1/20 0.51
TSHR P16473 1/20 0.51
KDM4E B2RXH2 1/20 0.49
TP53 P04637 1/20 0.49
HPGD P15428 1/20 0.49
HTT P42858 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2428577 0.94 HSP90AA1 (0.76) HSP90AA1HSP90AB1NPC1ALDH1A1MAPT
SCHEMBL2428574 0.94 HSP90AA1 (0.76) HSP90AA1HSP90AB1NPC1ALDH1A1MAPT
SCHEMBL3979059 0.93 HSP90AA1 (0.75) HSP90AA1HSP90AB1NPC1ALDH1A1MAPT
SCHEMBL2429436 0.93 HSP90AA1 (1.00) HSP90AA1HSP90AB1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL2429433 0.93 HSP90AA1 (1.00) HSP90AA1HSP90AB1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL2429266 0.92 HSP90AA1 (0.77) HSP90AA1HSP90AB1NPC1ALDH1A1MAPT
SCHEMBL2429263 0.92 HSP90AA1 (0.77) HSP90AA1HSP90AB1NPC1ALDH1A1MAPT
SCHEMBL3977441 0.92 HSP90AA1 (0.77) HSP90AA1HSP90AB1RAB9A
SCHEMBL2426780 0.92 HSP90AA1 (0.75) HSP90AA1HSP90AB1MAPTLMNATP53
SCHEMBL2426782 0.92 HSP90AA1 (0.75) HSP90AA1HSP90AB1MAPTLMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2074120-A1 TROPANE COMPOUNDS Exelixis, Inc. (US) 2009-07-01 EP disclosed
WO-2009055077-A1 TROPANE COMPOUNDS EXELIXIS, INC. (US) 2009-04-30 WO disclosed