⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL351887 | 0.89 | ADRA2A (0.32) | — | |
| SCHEMBL27966021 | 0.87 | ADRA2A (0.32) | — | |
| SCHEMBL27966218 | 0.87 | ADRA2A (0.32) | — | |
| SCHEMBL381338 | 0.87 | ADRA2A (0.32) | — | |
| SCHEMBL10410293 | 0.87 | ADRA2A (0.32) | — | |
| SCHEMBL471908 | 0.87 | ADRA2A (0.32) | — | |
| SCHEMBL9003861 | 0.87 | ADRA2A (0.32) | — | |
| SCHEMBL27490832 | 0.87 | ADRA2A (0.32) | — | |
| SCHEMBL381129 | 0.87 | ADRA2A (0.32) | — | |
| SCHEMBL353044 | 0.84 | ADRA2A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102282149-A | Process for the manufacture of (+)-biotin | — | 2011-12-14 | — | — | CN | claimed |
| CN-101284837-B | Stereoselective total synthesis method of (+)-biotin | UNIV FUDAN | 2011-07-20 | — | — | CN | claimed |
| WO-2009049476-A1 | PROCESS FOR THE MANUFACTURE OF (+)-BIOTIN | DSM IP ASSETS B.V. (NL) | 2009-04-23 | — | — | WO | claimed |
| CN-101284837-A | Stereoselective total synthesis method of (+)-biotin | UNIV FUDAN (CN) | 2008-10-15 | — | — | CN | claimed |
| CN-101284837-B | Stereoselective total synthesis method of (+)-biotin | UNIV FUDAN | 2011-07-20 | — | — | CN | disclosed |
| CN-101284837-A | Stereoselective total synthesis method of (+)-biotin | UNIV FUDAN (CN) | 2008-10-15 | — | — | CN | disclosed |