Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980507 | 0.93 | MAPT (0.43) | MAPTLMNADRD4HTR1AMAPK1 | |
| SCHEMBL3977781 | 0.86 | POLB (0.48) | MAPTLMNADRD4DRD2HTR1A | |
| SCHEMBL3196255 | 0.85 | DRD3 (0.53) | DRD4DRD2HTR1ADRD3 | |
| SCHEMBL3978985 | 0.81 | DRD4 (0.43) | MAPTDRD4DRD2HTR1A | |
| SCHEMBL3189295 | 0.80 | HTR7 (0.50) | MAPTLMNADRD4DRD2HTR1A | |
| SCHEMBL13484920 | 0.79 | DRD3 (0.55) | DRD4DRD2HTR1ADRD3 | |
| SCHEMBL3977788 | 0.78 | HSD17B10 (0.54) | MAPTLMNADRD4DRD2HTR1A | |
| SCHEMBL3980711 | 0.76 | POLB (0.43) | MAPTDRD4DRD2ALDH1A1CACNA1G | |
| SCHEMBL13484977 | 0.75 | DRD3 (0.56) | DRD4DRD2HTR1ADRD3 | |
| SCHEMBL3205532 | 0.75 | DRD3 (0.51) | MAPTDRD4DRD2HTR1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057138-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | Pierre Fabre Medicament (FR) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008009741-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2008-01-24 | — | — | WO | disclosed |