Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914901 | 0.91 | ALDH1A1 (0.48) | HSD17B10CTSDALDH1A1KMT2ATDP1 | |
| SCHEMBL31688378 | 0.91 | ALDH1A1 (0.48) | HSD17B10CTSDALDH1A1KMT2ATDP1 | |
| SCHEMBL18486613 | 0.83 | HSD17B10 (0.42) | HSD17B10CTSDALDH1A1KMT2ATDP1 | |
| SCHEMBL18486615 | 0.83 | HSD17B10 (0.42) | HSD17B10CTSDALDH1A1KMT2ATDP1 | |
| Butane SCHEMBL27519037 | 0.79 | HSD17B10 (0.60) | HSD17B10CTSDALDH1A1KMT2ATDP1 | |
| SCHEMBL31688384 | 0.79 | ALDH1A1 (0.51) | HSD17B10CTSDALDH1A1KMT2ATDP1 | |
| SCHEMBL917444 | 0.79 | ALDH1A1 (0.51) | HSD17B10CTSDALDH1A1KMT2ATDP1 | |
| SCHEMBL18486609 | 0.79 | POLB (0.39) | HSD17B10CTSDALDH1A1KMT2ATP53 | |
| SCHEMBL18486605 | 0.79 | POLB (0.39) | HSD17B10CTSDALDH1A1KMT2ATP53 | |
| SCHEMBL16146801 | 0.77 | TDP1 (0.62) | HSD17B10ALDH1A1KMT2ATDP1GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057173-A1 | AMIDES AS SPHINGOMYELINE INHIBITORS | Novartis AG (CH) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008022771-A1 | AMIDES AS SPHINGOMYELINE INHIBITORS | NOVARTIS AG (CH) | 2008-02-28 | — | — | WO | disclosed |