Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 14/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9720665 | 0.76 | ATM (0.51) | MEN1KMT2AOPRD1USP2OPRM1 | |
| Histamine SCHEMBL4064919 | 0.75 | HRH1 (0.38) | — | |
| SCHEMBL219432 | 0.75 | MEN1 (1.00) | MEN1KMT2AOPRD1SLC6A4USP2 | |
| Histamine SCHEMBL28074178 | 0.75 | HRH1 (0.42) | CYP2C9CYP2C19 | |
| SCHEMBL2794662 | 0.75 | MEN1 (1.00) | MEN1KMT2AOPRD1SLC6A4USP2 | |
| Histamine SCHEMBL29158012 | 0.74 | HRH4 (0.34) | CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL7006476 | 0.73 | MEN1 (0.96) | MEN1KMT2AOPRD1SLC6A4USP2 | |
| SCHEMBL27485345 | 0.73 | MEN1 (0.96) | MEN1KMT2AOPRD1SLC6A4USP2 | |
| Hydrochloric Acid SCHEMBL11456225 | 0.73 | MEN1 (0.96) | MEN1KMT2AOPRD1SLC6A4USP2 | |
| Fluoride SCHEMBL27959930 | 0.73 | MEN1 (0.96) | MEN1KMT2AOPRD1SLC6A4USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061465-A1 | CHEWABLE FORMULATIONS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-05-14 | — | — | WO | disclosed |