Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 10/20 | 0.50 |
| ▸ | ACLY | P53396 | 3/20 | 0.40 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982084 | 0.92 | METAP2 (0.59) | METAP2ACLYSLC16A3 | |
| SCHEMBL3979854 | 0.92 | METAP2 (0.56) | METAP2ACLYSLC16A3 | |
| SCHEMBL3978425 | 0.85 | METAP2 (0.64) | METAP2SLC16A3 | |
| SCHEMBL3981528 | 0.81 | METAP2 (0.46) | METAP2ACLYSLC16A3 | |
| SCHEMBL3981532 | 0.81 | METAP2 (0.46) | METAP2ACLYSLC16A3 | |
| SCHEMBL3986601 | 0.79 | METAP2 (0.53) | METAP2 | |
| SCHEMBL3988657 | 0.79 | METAP2 (0.56) | METAP2ACLY | |
| SCHEMBL4251300 | 0.74 | METAP2 (0.54) | METAP2SLC16A3 | |
| SCHEMBL4251296 | 0.74 | METAP2 (0.54) | METAP2SLC16A3 | |
| SCHEMBL3980835 | 0.72 | METAP2 (0.56) | METAP2ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491718-B2 | Sulfonamides having antiangiogenic and anticancer activity | ABBOTT LABORATORIES (US) | 2009-02-17 | — | — | US | disclosed |
| US-20040157836-A1 | Sulfonamides having antiangiogenic and anticancer activity | ABBOTT LABORATORIES | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157836-A1 | Sulfonamides having antiangiogenic and anticancer activity | METAP2, METAP1, DNPEP | METAP2 1/4885ACLY 2986/4885SLC16A3 929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.