Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.53 |
| ▸ | AURKA | O14965 | 5/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.44 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | LYN | P07948 | 4/20 | 0.43 |
| ▸ | RET | P07949 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.43 |
| ▸ | FLT1 | P17948 | 4/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.43 |
| ▸ | AXL | P30530 | 4/20 | 0.43 |
| ▸ | FLT3 | P36888 | 4/20 | 0.43 |
| ▸ | FRK | P42685 | 4/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977000 | 0.89 | KDR (0.55) | KDRAURKAAURKBEPHB4EIF2AK1 | |
| SCHEMBL3985880 | 0.84 | KDR (0.48) | KDRAURKAAURKBEPHB4EIF2AK1 | |
| SCHEMBL3981430 | 0.83 | KDR (0.55) | KDRAURKAAURKBEIF2AK3ROCK2 | |
| SCHEMBL3979285 | 0.78 | KDR (0.44) | KDRAURKAAURKBEPHB4EIF2AK1 | |
| SCHEMBL3979533 | 0.75 | KDR (0.51) | KDRAURKAAURKBEPHB4EIF2AK1 | |
| SCHEMBL24475772 | 0.75 | KDM4E (0.55) | — | |
| SCHEMBL24454171 | 0.72 | KDM4E (0.52) | — | |
| SCHEMBL3533248 | 0.72 | KDR (0.68) | KDRAURKAAURKBEPHB4ROCK2 | |
| SCHEMBL24475836 | 0.72 | KDM4E (0.44) | — | |
| SCHEMBL3531281 | 0.71 | KDR (1.00) | KDRAURKAAURKBEPHB4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051982-A1 | 6,6-BICYCLIC RING SUBSTITUTED SULFUR CONTAINING HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2009-04-29 | — | — | EP | claimed |
| WO-2008018881-A1 | 6,6-BICYCLIC RING SUBSTITUTED SULFUR CONTAINING HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | claimed |
| US-20070032512-A1 | 6,6-Bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS, INC., | 2007-02-08 | — | — | US | claimed |
| US-7566721-B2 | Substituted thienol[2,3-d]pyrimidines as kinase inhibitors | OSI PHARMACEUTICALS, INC. (US) | 2009-07-28 | — | — | US | disclosed |
| EP-2051982-A1 | 6,6-BICYCLIC RING SUBSTITUTED SULFUR CONTAINING HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008018881-A1 | 6,6-BICYCLIC RING SUBSTITUTED SULFUR CONTAINING HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |
| US-20070032512-A1 | 6,6-Bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS, INC., | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032512-A1 | 6,6-Bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors | IGF1R, BRCA1, MAP2K6 | KDR 2130/4885AURKA 1878/4885AURKB 1176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.