Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.67 |
| ▸ | MMP9 | P14780 | 7/20 | 0.67 |
| ▸ | MMP12 | P39900 | 7/20 | 0.67 |
| ▸ | MMP14 | P50281 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP16 | P51512 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316248 | 0.88 | MMP2 (0.85) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL314813 | 0.85 | MMP2 (0.86) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL315440 | 0.83 | MMP2 (0.92) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL8230220 | 0.82 | MEN1 (0.61) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL8228138 | 0.81 | MMP2 (0.59) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL10049368 | 0.81 | MMP2 (0.62) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL315516 | 0.81 | MMP2 (0.87) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL8223093 | 0.81 | MMP2 (0.61) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL315109 | 0.80 | MMP2 (0.93) | MMP2MMP9MMP12MMP14MEN1 | |
| SCHEMBL315140 | 0.80 | MMP2 (1.00) | MMP2MMP9MMP12MMP14MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2009545556-A | — | — | 2009-12-24 | — | — | JP | claimed |
| EP-2059500-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | Bracco Imaging S.p.A (IT) | 2009-05-20 | — | — | EP | claimed |
| WO-2008015139-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | BRACCO IMAGING SPA (IT) | 2008-02-07 | — | — | WO | claimed |
| EP-2059500-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | Bracco Imaging S.p.A (IT) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008015139-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | BRACCO IMAGING SPA (IT) | 2008-02-07 | — | — | WO | disclosed |