Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 10/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.35 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27985450 | 0.89 | PDK1 (0.59) | PDK1PIK3CAPIK3CDPIK3R2PIK3CB | |
| SCHEMBL27785370 | 0.85 | PDK1 (0.62) | PDK1PIK3CAPIK3CDPIK3R2PIK3CB | |
| SCHEMBL28132263 | 0.85 | PDK1 (0.62) | PDK1PIK3CAPIK3CDPIK3R2PIK3CB | |
| SCHEMBL28133029 | 0.85 | PDK1 (0.62) | PDK1PIK3CAPIK3CDPIK3R2PIK3CB | |
| SCHEMBL3029708 | 0.83 | PDK1 (0.61) | PDK1PIK3CAPIK3CDPIK3R2PIK3CB | |
| SCHEMBL2934637 | 0.83 | PDK1 (0.61) | PDK1PIK3CAPIK3CDPIK3R2PIK3CB | |
| SCHEMBL571075 | 0.83 | PDK1 (0.61) | PDK1PIK3CAPIK3CDPIK3R2PIK3CB | |
| SCHEMBL31622172 | 0.81 | PDK1 (0.59) | PDK1PIK3CAPIK3CDPIK3R2PIK3CB | |
| SCHEMBL11949265 | 0.81 | PDK1 (0.59) | PDK1PIK3CAPIK3CDPIK3R2PIK3CB | |
| SCHEMBL5369230 | 0.80 | PDK1 (0.63) | PDK1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059516-A1 | PYRIDINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (publ) (SE) | 2009-05-20 | — | — | EP | claimed |
| WO-2008025798-A1 | PYRIDINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2008-03-06 | — | — | WO | claimed |