Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.83 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.58 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.58 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.58 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.55 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.55 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1885089 | 0.91 | HDAC1 (1.00) | HDAC1SENP5SENP2SENP1HDAC2 | |
| SCHEMBL4075809 | 0.86 | HDAC1 (0.63) | HDAC1NR1H4CYP2C9CYP2C19PPARG | |
| SCHEMBL3568348 | 0.83 | HDAC2 (0.72) | HDAC1SENP5SENP2SENP1HDAC2 | |
| SCHEMBL3565538 | 0.81 | HDAC1 (0.74) | HDAC1ERCC1ERCC4BCL2L1HDAC2 | |
| SCHEMBL3570753 | 0.80 | HDAC1 (0.57) | HDAC1SENP5SENP2SENP1BCL2L1 | |
| SCHEMBL1884493 | 0.79 | HDAC1 (0.78) | HDAC1HDAC2HDAC3HDAC6CYP2C19 | |
| SCHEMBL1889752 | 0.79 | HDAC1 (0.78) | HDAC1HDAC2HDAC3NCOR2HDAC6 | |
| SCHEMBL4255241 | 0.78 | HDAC1 (0.82) | HDAC1BCL2L1 | |
| SCHEMBL8291123 | 0.78 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC6CYP2C9 | |
| SCHEMBL1890070 | 0.78 | HDAC1 (0.81) | HDAC1HDAC2HDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677731-A4 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA INC (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1677731-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | Aton Pharma, Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005034880-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA, INC. (US) | 2005-04-21 | — | — | WO | disclosed |