Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.82 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1886196 | 0.90 | HDAC1 (1.00) | HDAC1 | |
| SCHEMBL1890182 | 0.83 | HDAC1 (0.87) | HDAC1 | |
| SCHEMBL4083883 | 0.81 | HDAC1 (0.69) | HDAC1BCL2L1TBXAS1 | |
| SCHEMBL1888083 | 0.80 | HDAC1 (1.00) | HDAC1 | |
| SCHEMBL1887887 | 0.79 | HDAC1 (1.00) | HDAC1 | |
| SCHEMBL3982575 | 0.78 | HDAC1 (0.83) | HDAC1BCL2L1 | |
| SCHEMBL3565538 | 0.77 | HDAC1 (0.74) | HDAC1BCL2L1ALDH1A1GAAMAPT | |
| SCHEMBL26603422 | 0.77 | AKR1C3 (0.57) | HDAC1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3570753 | 0.77 | HDAC1 (0.57) | HDAC1BCL2L1TBXAS1 | |
| SCHEMBL4552001 | 0.76 | BCL2L1 (0.55) | HDAC1BCL2L1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677731-A4 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA INC (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1677731-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | Aton Pharma, Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005034880-A2 | THIOPHENE AND BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES | ATON PHARMA, INC. (US) | 2005-04-21 | — | — | WO | disclosed |