Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.56 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | TOP2A | P11388 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1005317 | 0.86 | HTR3A (0.54) | HTR3AELANETOP2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1005664 | 0.84 | HTR3A (0.54) | HTR3AELANETOP2AIDO1MAOA | |
| SCHEMBL1008152 | 0.83 | TOP2A (0.45) | HTR3ATOP2AIDO1MAOAMAOB | |
| SCHEMBL1003671 | 0.82 | HTR3A (0.41) | HTR3AELANETOP2AIDO1MAOA | |
| SCHEMBL1006835 | 0.82 | HTR3A (0.41) | HTR3ATOP2AIDO1MAOAMAOB | |
| Hydrochloric Acid SCHEMBL1004329 | 0.82 | HTR3A (0.41) | HTR3ATOP2AIDO1MAOAMAOB | |
| Hydrochloric Acid SCHEMBL1007973 | 0.82 | HTR3A (0.41) | HTR3AELANETOP2AIDO1MAOA | |
| SCHEMBL1006463 | 0.81 | HTR3A (0.43) | HTR3AELANETOP2AIDO1MAOA | |
| SCHEMBL27776060 | 0.79 | KDM4E (0.48) | TOP2AALDH1A1SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL19298146 | 0.78 | IDO1 (0.44) | HTR3AELANETOP2AIDO1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528225-B | 2-aminobenzoxazole carboxamides as 5HT3 modulators | ALBANY MOLECULAR RES INC | 2013-07-17 | — | — | CN | disclosed |
| CN-101528225-A | 2-aminobenzoxazole carboxamides as 5HT3 modulators | AMR TECHNOLOGY INC (US) | 2009-09-09 | — | — | CN | disclosed |
| EP-2061460-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | Albany Molecular Research, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008019372-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-02-14 | — | — | WO | disclosed |