Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.67 |
| ▸ | KDR | P35968 | 7/20 | 0.67 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982541 | 0.93 | IGF1R (0.77) | IGF1RFGFR1KDRINSR | |
| SCHEMBL13844709 | 0.88 | FGFR1 (0.86) | IGF1RFGFR1KDRINSRABCB1 | |
| Hydrochloric Acid SCHEMBL4106603 | 0.87 | FGFR1 (0.85) | IGF1RFGFR1KDRINSRABCB1 | |
| SCHEMBL3950749 | 0.86 | IGF1R (0.67) | IGF1RFGFR1KDRINSREGFR | |
| SCHEMBL3981643 | 0.86 | IGF1R (0.50) | IGF1RFGFR1KDRINSREGFR | |
| SCHEMBL3940507 | 0.84 | IGF1R (0.66) | IGF1RFGFR1KDRINSR | |
| SCHEMBL5096569 | 0.83 | IGF1R (0.53) | IGF1RFGFR1KDRINSRCLK4 | |
| SCHEMBL3934716 | 0.83 | NR3C2 (0.44) | IGF1RFGFR1KDRABCB1HTR1A | |
| SCHEMBL4015520 | 0.82 | IGF1R (0.54) | IGF1RFGFR1KDRINSRNTRK1 | |
| SCHEMBL3985665 | 0.81 | IGF1R (0.47) | IGF1RFGFR1KDRINSREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |