Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | GRK6 | P43250 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | GRK4 | P32298 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.38 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4094616 | 0.84 | JAK2 (0.51) | IGF1RKDRFGFR1INSREGFR | |
| SCHEMBL3985659 | 0.84 | JAK2 (0.51) | IGF1RKDRFGFR1INSREGFR | |
| SCHEMBL3983403 | 0.81 | IGF1R (0.67) | IGF1RKDRFGFR1INSREGFR | |
| SCHEMBL3934716 | 0.79 | NR3C2 (0.44) | IGF1RKDRFGFR1EGFRNTRK1 | |
| SCHEMBL3950749 | 0.79 | IGF1R (0.67) | IGF1RKDRFGFR1INSREGFR | |
| SCHEMBL3981643 | 0.78 | IGF1R (0.50) | IGF1RKDRFGFR1INSREGFR | |
| SCHEMBL3940507 | 0.78 | IGF1R (0.66) | IGF1RKDRFGFR1INSR | |
| SCHEMBL4015520 | 0.77 | IGF1R (0.54) | IGF1RKDRFGFR1INSRNTRK1 | |
| SCHEMBL3932077 | 0.77 | IGF1R (0.59) | IGF1RKDRFGFR1INSRROCK1 | |
| SCHEMBL5096569 | 0.76 | IGF1R (0.53) | IGF1RKDRFGFR1INSRCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |