Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.58 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3983734 | 0.86 | BRAF (0.59) | BRAFTRPV4 | |
| SCHEMBL3978261 | 0.83 | BRAF (0.53) | BRAFTRPV4RAF1MAPK14 | |
| SCHEMBL3977979 | 0.74 | BRAF (0.70) | BRAF | |
| SCHEMBL3978525 | 0.74 | BRAF (1.00) | BRAF | |
| SCHEMBL3975710 | 0.74 | BRAF (0.57) | BRAFRAF1MAPK14 | |
| SCHEMBL3982343 | 0.71 | BRAF (1.00) | BRAF | |
| SCHEMBL4205781 | 0.70 | BRAF (0.55) | BRAF | |
| SCHEMBL15444870 | 0.70 | TRPV4 (1.00) | TRPV4 | |
| SCHEMBL4655830 | 0.70 | BRAF (0.69) | BRAFRAF1MAPK14 | |
| SCHEMBL3974567 | 0.70 | BRAF (0.53) | BRAFTRPV4MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | US | disclosed |
| WO-2009059272-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | BRAF, ARAF, RAF1 | BRAF 1/4885TRPV4 2674/4885RAF1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.