Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.59 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.56 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1842407 | 0.89 | S1PR1 (0.61) | S1PR1S1PR3S1PR5 | |
| SCHEMBL402373 | 0.88 | S1PR1 (0.72) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1842405 | 0.86 | S1PR1 (0.62) | S1PR1S1PR3S1PR5 | |
| SCHEMBL399923 | 0.86 | S1PR1 (0.66) | S1PR1S1PR3S1PR5 | |
| SCHEMBL404306 | 0.84 | S1PR1 (0.79) | S1PR1S1PR3S1PR5 | |
| SCHEMBL10113775 | 0.83 | S1PR1 (0.59) | S1PR1S1PR3S1PR5 | |
| SCHEMBL399437 | 0.83 | S1PR1 (0.74) | S1PR1S1PR3S1PR5 | |
| SCHEMBL403147 | 0.83 | S1PR1 (0.60) | S1PR1S1PR3S1PR5 | |
| SCHEMBL404436 | 0.82 | S1PR1 (0.65) | S1PR1S1PR3S1PR5 | |
| SCHEMBL403038 | 0.81 | S1PR1 (0.67) | S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101775-B2 | Indole derivatives as S1P1 Receptor | GLAXO GROUP LIMITED (GB) | 2012-01-24 | — | — | US | disclosed |
| EP-2091949-B1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2011-05-18 | — | — | EP | disclosed |