Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.56 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL398386 | 0.88 | S1PR1 (0.59) | S1PR1S1PR3S1PR5 | |
| SCHEMBL403364 | 0.85 | S1PR1 (0.85) | S1PR1CYP2C9S1PR3S1PR5 | |
| SCHEMBL403211 | 0.84 | S1PR1 (1.00) | S1PR1CYP2C9S1PR3S1PR5 | |
| SCHEMBL401724 | 0.83 | S1PR1 (0.92) | S1PR1CYP2C9S1PR3S1PR5 | |
| SCHEMBL3216955 | 0.83 | S1PR1 (0.78) | S1PR1CYP2C9S1PR3 | |
| SCHEMBL10113772 | 0.82 | S1PR1 (0.75) | S1PR1CYP2C9S1PR3S1PR5 | |
| SCHEMBL404631 | 0.82 | S1PR1 (0.77) | S1PR1CYP2C9S1PR3 | |
| SCHEMBL3744606 | 0.81 | S1PR1 (0.60) | S1PR1CYP2C9S1PR3 | |
| SCHEMBL403942 | 0.80 | S1PR1 (0.78) | S1PR1CYP2C9S1PR3 | |
| SCHEMBL12600636 | 0.80 | S1PR1 (0.75) | S1PR1CYP2C9S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101775-B2 | Indole derivatives as S1P1 Receptor | GLAXO GROUP LIMITED (GB) | 2012-01-24 | — | — | US | disclosed |
| EP-2091949-B1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2011-05-18 | — | — | EP | disclosed |