Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.37 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3991224 | 0.78 | TSHR (0.49) | PTGESTSHR | |
| SCHEMBL11131644 | 0.77 | TSHR (0.64) | MTNR1AMTNR1BCETPTSHRCNR1 | |
| SCHEMBL22340523 | 0.77 | MTNR1A (0.51) | MTNR1AMTNR1BCETPLMNAMAPT | |
| SCHEMBL25079727 | 0.74 | MAOB (0.51) | MTNR1AMTNR1BCETPLMNAMAPT | |
| SCHEMBL3985381 | 0.74 | TSHR (0.38) | FFAR1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL22355539 | 0.74 | MTNR1A (0.49) | MTNR1AMTNR1BCETPLMNAMAPT | |
| SCHEMBL3984033 | 0.73 | KDM4E (0.60) | FFAR1 | |
| SCHEMBL22355543 | 0.73 | MTNR1A (0.55) | MTNR1AMTNR1BLMNAMAPTHTT | |
| SCHEMBL3743961 | 0.72 | CASR (0.61) | FFAR1PTGESLMNAHTT | |
| SCHEMBL20028557 | 0.71 | AOC3 (0.59) | MTNR1AMTNR1BCETPTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061449-A1 | SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES | Leo Pharma A/S (DK) | 2009-05-27 | — | — | EP | claimed |
| WO-2008019690-A1 | SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES | LEO PHARMA A/S (DK) | 2008-02-21 | — | — | WO | claimed |
| EP-2061449-A1 | SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES | Leo Pharma A/S (DK) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008019690-A1 | SUBSTITUTED ACETYLENIC COMPOUNDS USEFUL FOR THE TREATMENT OF DISEASES | LEO PHARMA A/S (DK) | 2008-02-21 | — | — | WO | disclosed |