⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7081970 | 0.72 | — | — | |
| SCHEMBL430949 | 0.72 | — | — | |
| SCHEMBL1289421 | 0.69 | MEN1 (0.32) | — | |
| SCHEMBL8009 | 0.69 | — | — | |
| SCHEMBL419805 | 0.69 | MEN1 (0.32) | — | |
| SCHEMBL7081966 | 0.67 | — | — | |
| SCHEMBL8008 | 0.67 | — | — | |
| Ammonia Solution, Strong SCHEMBL16110998 | 0.67 | — | — | |
| SCHEMBL6847438 | 0.67 | — | — | |
| SCHEMBL12687036 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032530-A1 | PYRROLIDINE COMPOUNDS AS RENIN INHIBITORS | Novartis AG (CH) | 2009-03-11 | — | — | EP | disclosed |
| EP-1940789-A1 | METHODS AND COMPOUNDS FOR PREPARING CC-1065 ANALOGS | Medarex, Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007144128-A1 | PYRROLIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007051081-A1 | METHODS AND COMPOUNDS FOR PREPARING CC-1065 ANALOGS | MEDAREX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
| EP-0258183-A2 | Process for the preparation of 5-amino-4-hydroxyvaleric-acid derivatives | CIBA-GEIGY AG (CH) | 1988-03-02 | — | — | EP | disclosed |