Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 9/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1006857 | 1.00 | HTR3A (0.53) | HTR3AMDM2KCNH2LRRK2ALDH1A1 | |
| SCHEMBL1004321 | 0.89 | HTR3A (0.51) | HTR3AKCNH2NPC1RAB9A | |
| SCHEMBL1005156 | 0.89 | HTR3A (0.51) | HTR3AKCNH2NPC1RAB9A | |
| SCHEMBL1004322 | 0.89 | HTR3A (0.51) | HTR3AKCNH2NPC1RAB9A | |
| SCHEMBL1007977 | 0.87 | HTR3A (0.52) | HTR3AKCNH2ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL1007978 | 0.87 | HTR3A (0.52) | HTR3AKCNH2ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL1006355 | 0.86 | HTR3A (0.52) | HTR3AKCNH2ALDH1A1L3MBTL1FKBP1A | |
| SCHEMBL1006356 | 0.86 | HTR3A (0.52) | HTR3AKCNH2ALDH1A1L3MBTL1FKBP1A | |
| SCHEMBL1006363 | 0.86 | HTR3A (0.52) | HTR3AKCNH2ALDH1A1L3MBTL1FKBP1A | |
| SCHEMBL1005780 | 0.84 | HTR3A (0.49) | HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061460-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | Albany Molecular Research, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008019372-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-02-14 | — | — | WO | disclosed |