Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3984630 | 0.87 | MAOB (0.38) | TOP2AALOX5HTR3AKCNH2KDM4E | |
| SCHEMBL4308323 | 0.74 | TOP2A (0.51) | TOP2AHSD17B10HTR3AKCNH2PKN1 | |
| SCHEMBL1007865 | 0.72 | TOP2A (0.43) | TOP2AHSD17B10HTR3AKCNH2PKN1 | |
| SCHEMBL14721812 | 0.70 | GAA (0.42) | ALOX5KDM4EALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL1398896 | 0.70 | TOP2A (0.59) | TOP2AHSD17B10PKN1PKN2RIPK1 | |
| SCHEMBL4311643 | 0.69 | HTR3A (0.48) | TOP2AHSD17B10HTR3AKCNH2RIPK1 | |
| SCHEMBL1003473 | 0.69 | TOP2A (0.45) | TOP2AHSD17B10ALOX5HTR3AKCNH2 | |
| SCHEMBL1005898 | 0.69 | TOP2A (0.57) | TOP2AHSD17B10PKN1PKN2RIPK1 | |
| SCHEMBL1121666 | 0.69 | TOP2A (0.57) | TOP2AHSD17B10PKN1PKN2RIPK1 | |
| SCHEMBL1004337 | 0.69 | TOP2A (0.57) | TOP2AHSD17B10HTR3APKN1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061460-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | Albany Molecular Research, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008019372-A2 | 2-AMINOBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-02-14 | — | — | WO | disclosed |