Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 2/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3988077 | 0.76 | XPO1 (0.40) | XPO1TYK2JAK2PIM1PIM2 | |
| SCHEMBL1702103 | 0.75 | XPO1 (0.47) | XPO1PSMB8L3MBTL1KDM4EAR | |
| SCHEMBL3992045 | 0.73 | XPO1 (0.46) | XPO1L3MBTL1KDM4EMAPTAR | |
| SCHEMBL3990548 | 0.71 | XPO1 (0.41) | XPO1JAK2KDM4EMAPT | |
| SCHEMBL1702476 | 0.70 | CHEK1 (0.44) | XPO1PSMB8TYK2JAK2L3MBTL1 | |
| SCHEMBL1702529 | 0.68 | XPO1 (0.47) | XPO1L3MBTL1KDM4EARPIM1 | |
| SCHEMBL18434270 | 0.68 | RAB9A (0.55) | XPO1L3MBTL1KDM4EMAPTCHEK1 | |
| SCHEMBL17651740 | 0.68 | CHUK (0.50) | L3MBTL1KDM4EMAPTGRM4 | |
| SCHEMBL22134943 | 0.67 | XPO1 (0.49) | XPO1TYK2JAK2L3MBTL1KDM4E | |
| SCHEMBL30603860 | 0.66 | XPO1 (0.48) | XPO1L3MBTL1KDM4EMAPTPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521560-B2 | 2-substituted quinoline compounds and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-04-21 | — | — | US | disclosed |
| US-7521560-B2 | 2-substituted quinoline compounds and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-04-21 | — | — | US | disclosed |
| EP-1781637-A1 | 2-SUBSTITUTED QUINOLINE COMPOUNDS AND THEIR USES AS INHIBITORS OF THE IGE RECEPTOR SIGNALING CASCADE | Rigel Pharmaceuticals, Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| US-20060040982-A1 | 2-Substituted quinoline compounds and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2006-02-23 | — | — | US | disclosed |
| WO-2006004865-A1 | 2-SUBSTITUTED QUINOLINE COMPOUNDS AND THEIR USES AS INHIBITORS OF THE IGE RECEPTOR SIGNALING CASCADE | RIGEL PHARMACEUTICALS, INC. (US) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040982-A1 | 2-Substituted quinoline compounds and their uses | FCER2, LTB4R2, CYSLTR2 | XPO1 2363/4885PSMB8 2170/4885TYK2 734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.