SCHEMBL3984986

SCHEMBL3984986

c1ccc(OC2CCCNC2)nc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 4/20 0.55
CHRNA4 P43681 4/20 0.55
ROCK1 Q13464 5/20 0.49
ROCK2 O75116 3/20 0.49
KCNH2 Q12809 1/20 0.49
HTR1A P08908 1/20 0.46
SLC6A2 P23975 1/20 0.46
IKBKB O14920 1/20 0.45
CHUK O15111 1/20 0.45
CHRM2 P08172 1/20 0.45
CHRM1 P11229 1/20 0.45
CHRM3 P20309 1/20 0.45
MKNK1 Q9BUB5 2/20 0.44
PIM1 P11309 1/20 0.42
PIM3 Q86V86 1/20 0.42
PIM2 Q9P1W9 1/20 0.42
ALOX5AP P20292 1/20 0.42
FEN1 P39748 1/20 0.42
CDC42BPB Q9Y5S2 2/20 0.42
CDC42BPA Q5VT25 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3296534 0.98 CHRNB2 (0.54) CHRNB2CHRNA4ROCK1ROCK2KCNH2
SCHEMBL31234233 0.90 CHRNB2 (0.53) CHRNB2CHRNA4HTR1ASLC6A2MKNK1
SCHEMBL2264859 0.90 CHRNB2 (0.53) CHRNB2CHRNA4HTR1ASLC6A2MKNK1
SCHEMBL3655274 0.90 CHRNB2 (0.53) CHRNB2CHRNA4HTR1ASLC6A2MKNK1
SCHEMBL29994416 0.90 CHRNB2 (0.53) CHRNB2CHRNA4HTR1ASLC6A2MKNK1
SCHEMBL2269304 0.90 CHRNB2 (0.53) CHRNB2CHRNA4HTR1ASLC6A2MKNK1
Hydrochloric Acid SCHEMBL22031566 0.89 CHRNB2 (0.51) CHRNB2CHRNA4ROCK1ROCK2HTR1A
Hydrochloric Acid SCHEMBL31656540 0.89 CHRNB2 (0.51) CHRNB2CHRNA4ROCK1ROCK2HTR1A
Hydrochloric Acid SCHEMBL1953011 0.89 CHRNB2 (0.51) CHRNB2CHRNA4ROCK1ROCK2HTR1A
Hydrochloric Acid SCHEMBL28668620 0.89 CHRNB2 (0.51) CHRNB2CHRNA4ROCK1ROCK2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2118092-A1 NEW N, N'- 2,4-DIANILINOPYRIMIDINE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS ESSENTIALLY AS IKK INHIBITORS Sanofi-Aventis (FR) 2009-11-18 EP disclosed
WO-2009056693-A1 NOVEL DERIVATIVES OF N, N'- 2, 4-DIANILINOPYRIMIDINES, PREPARATION THEREOF AS MEDICAMENTS PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS IKK INHIBITORS SANOFI-AVENTIS (FR) 2009-05-07 WO disclosed
WO-2008099073-A1 N, N' -2, 4-DIANILINOPYRIMIDINES PREPARATION AND USE THEREOF AS IKK INHIBITORS PREPARATION AND TEH PHARMACUETICAL COMPOSITIONS THEREOF SANOFI-AVENTIS (FR) 2008-08-21 WO disclosed