Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.79 |
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.71 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30265317 | 0.91 | NPC1 (0.81) | NPC1LMNASMYD3EPHX1HDAC6 | |
| SCHEMBL3984993 | 0.89 | NPC1 (0.64) | NPC1LMNASMYD3EPHX1HDAC6 | |
| SCHEMBL21489973 | 0.88 | NPC1 (0.78) | NPC1LMNASMYD3EPHX1HDAC6 | |
| Hydrochloric Acid SCHEMBL2356279 | 0.88 | NPC1 (0.74) | NPC1LMNASMYD3EPHX1HDAC6 | |
| Hydrochloric Acid SCHEMBL30265370 | 0.88 | NPC1 (0.74) | NPC1LMNASMYD3EPHX1HDAC6 | |
| SCHEMBL19710135 | 0.88 | NPC1 (0.78) | NPC1LMNASMYD3EPHX1HDAC6 | |
| Hydrochloric Acid SCHEMBL30265427 | 0.87 | NPC1 (0.65) | NPC1LMNASMYD3EPHX1HDAC6 | |
| SCHEMBL1052812 | 0.86 | NPC1 (0.74) | NPC1LMNASMYD3EPHX1HDAC6 | |
| SCHEMBL10268218 | 0.86 | NPC1 (0.71) | NPC1LMNASMYD3EPHX1HDAC6 | |
| SCHEMBL112036 | 0.85 | NPC1 (0.69) | NPC1LMNASMYD3EPHX1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061786-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | Biogen Idec MA Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008030584-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF INTERLEUKIN- 1 RECEPTOR-ASSOCIATED KINASE | BIOGEN IDEC MA INC. (US) | 2008-03-13 | — | — | WO | disclosed |