⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL272220 | 0.75 | — | — | |
| SCHEMBL6002352 | 0.67 | NOTUM (0.56) | — | |
| SCHEMBL470129 | 0.62 | — | — | |
| SCHEMBL957412 | 0.62 | — | — | |
| SCHEMBL7045744 | 0.62 | — | — | |
| SCHEMBL5175494 | 0.62 | — | — | |
| SCHEMBL508672 | 0.62 | — | — | |
| SCHEMBL2868023 | 0.62 | — | — | |
| SCHEMBL18571212 | 0.62 | — | — | |
| SCHEMBL17153742 | 0.61 | NOTUM (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291921-A1 | INTEGRASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2009-11-26 | — | — | US | claimed |
| WO-2009067541-A2 | INTEGRASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2009-05-28 | — | — | WO | claimed |
| EP-2712315-B1 | LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE DISORDERS | ORYZON GENOMICS SA (ES) | 2021-11-24 | — | — | EP | disclosed |
| US-9908859-B2 | Lysine demethylase inhibitors for myeloproliferative disorders | ORYZON GENOMICS, S.A. (ES) | 2018-03-06 | — | — | US | disclosed |
| US-9790196-B2 | Lysine demethylase inhibitors for diseases and disorders associated with Flaviviridae | ORYZON GENOMICS S.A. (ES) | 2017-10-17 | — | — | US | disclosed |
| US-20170209432-A1 | LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISEASES OR DISORDERS | ORYZON GENOMICS SA (ES) | 2017-07-27 | — | — | US | disclosed |
| US-20160081947-A1 | SELECTIVE LSD1 AND DUAL LSD1/MAO-B INHIBITORS FOR MODULATING DISEASES ASSOCIATED WITH ALTERATIONS IN PROTEIN CONFORMATION | ORYZON GENOMICS S.A. (ES) | 2016-03-24 | — | — | US | disclosed |
| US-20150232436-A1 | LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE DISORDERS | ORYZON GENOMICS S.A. (ES) | 2015-08-20 | — | — | US | disclosed |
| US-20140329833-A1 | LYSINE DEMETHYLASE INHIBITORS FOR INFLAMMATORY DISEASES OR CONDITIONS | ORYZON GENOMICS, S.A (ES) | 2014-11-06 | — | — | US | disclosed |
| US-20140296255-A1 | LYSINE DEMETHYLASE INHIBITORS FOR THROMBOSIS AND CARDIOVASCULAR DISEASES | ORYZONG GENOMICS, S.A. (ES) | 2014-10-02 | — | — | US | disclosed |
| US-20140256742-A1 | LYSINE DEMETHYLASE INHIBITORS FOR DISEASES AND DISORDERS ASSOCIATED WITH FLAVIVIRIDAE | ORYZON GENOMICS S.A. (ES) | 2014-09-11 | — | — | US | disclosed |
| WO-2009067541-A2 | INTEGRASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2009-05-28 | — | — | WO | disclosed |
| US-7276517-B2 | Heterocyclic amide derivatives as inhibitors of glycogen phosphorylase | ASTRAZENECA AB (SE) | 2007-10-02 | — | — | US | disclosed |
| US-20070043069-A1 | 3-Amino-3,4-dihydro-1,5-naphthyridin-2(1H)-one and its dihydrochloride; intermediates for producing naphthyridinylaminocarbonyl-substituted pyrrolothiopyrans and imidazolothiopyrans | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | US | disclosed |
| US-7169927-B2 | Indole-amide derivatives and their use as glycogen phosphorylase inhibitors | ASTRAZENECA AB (SE) | 2007-01-30 | — | — | US | disclosed |
| US-7129249-B2 | Heterocyclic amide derivatives as inhibitors of glycogen phoshorylase | ASTRAZENECA AB (SE) | 2006-10-31 | — | — | US | disclosed |
| US-20050131016-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2005-06-16 | — | — | US | disclosed |
| US-20050131015-A1 | Heterocyclic amide derivatives as inhibitors of glycogen phoshorylase | ASTRAZENECA AB (SE) | 2005-06-16 | — | — | US | disclosed |
| EP-1480516-A1 | MICROBICIDAL AGENTS ON THE BASIS OF BIPHENYL BENZAMIDE DERIVATIVES | Bayer CropScience AG (DE) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003069995-A1 | MICROBICIDAL AGENTS ON THE BASIS OF BIPHENYL BENZAMIDE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2003-08-28 | — | — | WO | disclosed |