SCHEMBL6002352

SCHEMBL6002352

Nc1nnc(-c2nnc(N)o2)o1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 3/20 0.56
KDM4E B2RXH2 8/20 0.52
DGAT1 O75907 1/20 0.52
NPC1 O15118 4/20 0.46
RAB9A P51151 4/20 0.46
HSD17B10 Q99714 3/20 0.42
KMT2A Q03164 3/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
MEN1 O00255 2/20 0.35
ALDH1A1 P00352 2/20 0.35
PIM1 P11309 2/20 0.33
PIM3 Q86V86 2/20 0.33
PIM2 Q9P1W9 2/20 0.33
TP53 P04637 1/20 0.33
PKM P14618 1/20 0.33
MAPT P10636 2/20 0.31
GLA P06280 1/20 0.31
HPGD P15428 1/20 0.31
ALOX15 P16050 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL272220 0.81
SCHEMBL2766462 0.74 PKM (0.74) NOTUMKDM4EDGAT1NPC1RAB9A
SCHEMBL3979 0.74 NOTUM (1.00) NOTUMKDM4EDGAT1NPC1RAB9A
SCHEMBL18571212 0.73
SCHEMBL10759351 0.72 KDM4E (0.44) NOTUMKDM4EDGAT1NPC1RAB9A
SCHEMBL6903361 0.71 KDM4E (1.00) NOTUMKDM4EDGAT1NPC1RAB9A
SCHEMBL10112953 0.71 KDM4E (0.66) NOTUMKDM4EDGAT1NPC1RAB9A
SCHEMBL1500576 0.71 NOTUM (0.64) NOTUMKDM4EDGAT1NPC1RAB9A
SCHEMBL1143348 0.71 KDM4E (1.00) NOTUMKDM4EDGAT1NPC1RAB9A
SCHEMBL15718167 0.71 DGAT1 (1.00) NOTUMKDM4EDGAT1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7092608-B2 Polyimide optical materials, polyimide precursor solutions and optical waveguide elements KABUSHIKI KAISHA TOSHIBA (JP) 2006-08-15 US disclosed
US-7082244-B2 Polyimide optical materials, polyimide precursor solutions and optical waveguide elements KABUSHIKI KAISHA TOSHIBA (JP) 2006-07-25 US disclosed
US-20060159413-A1 POLYIMIDE OPTICAL MATERIALS, POLYIMIDE PRECURSOR SOLUTIONS AND OPTICAL WAVEGUIDE ELEMENTS KABUSHIKI KAISHA TOSHIBA (JP) 2006-07-20 US disclosed
US-20040197064-A1 Polyimide optical materials, polyimide precursor solutions and optical waveguide elements KABUSHIKI KAISHA TOSHIBA (JP) 2004-10-07 US disclosed