Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 5/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | GLS | O94925 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14266549 | 0.93 | TRPV1 (0.59) | RAF1EPHX2BRAFKDRTRPV1 | |
| SCHEMBL14266590 | 0.90 | KDR (0.53) | RAF1BRAFKDRKDM5B | |
| SCHEMBL3984330 | 0.89 | KDR (0.67) | RAF1BRAFKDRROCK2ROCK1 | |
| SCHEMBL3986441 | 0.89 | RAB9A (0.55) | RAF1BRAFKDRROCK2ROCK1 | |
| SCHEMBL3992512 | 0.88 | CA1 (0.54) | RAF1BRAFKDRROCK2ROCK1 | |
| SCHEMBL3986457 | 0.87 | NPC1 (0.56) | RAF1BRAFKDRKDM5B | |
| SCHEMBL3990381 | 0.86 | KDR (0.55) | RAF1BRAFKDRMAPK14RET | |
| SCHEMBL3989052 | 0.86 | BRAF (0.49) | RAF1BRAFKDRMAPK14RET | |
| SCHEMBL14266553 | 0.86 | BRAF (0.55) | RAF1BRAFKDRKDM5B | |
| SCHEMBL14266607 | 0.86 | BRAF (0.53) | RAF1BRAFKDRTRPV1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061761-A1 | PHENETHYLAMIDE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | Millennium Pharmaceuticals, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008030448-A1 | PHENETHYLAMIDE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-13 | — | — | WO | disclosed |