Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.51 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.51 |
| ▸ | IKBKB | O14920 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | BUB1 | O43683 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3987459 | 0.92 | JAK2 (0.41) | JAK2JAK3PDGFRBFLT3TBK1 | |
| SCHEMBL3987449 | 0.89 | JAK2 (0.46) | JAK2JAK3PDGFRBFLT3IKBKB | |
| SCHEMBL4729907 | 0.86 | JAK2 (0.51) | JAK2JAK3PDGFRBFLT3TBK1 | |
| SCHEMBL4728335 | 0.84 | JAK2 (0.48) | JAK2JAK3PDGFRBFLT3TBK1 | |
| SCHEMBL4731787 | 0.84 | JAK2 (0.45) | JAK2JAK3PDGFRBFLT3TBK1 | |
| SCHEMBL3992722 | 0.83 | MOK (0.43) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3988815 | 0.82 | MOK (0.42) | JAK2JAK3PIK3CAMTORPIK3CD | |
| SCHEMBL3987596 | 0.82 | MOK (0.38) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3988357 | 0.81 | AKT1 (0.43) | JAK2JAK3PIK3CAMTORPIK3CD | |
| SCHEMBL3990070 | 0.80 | JAK2 (0.41) | JAK2JAK3PIK3CAMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061784-A1 | 2-BENZIMIDAZOLYL-6-MORPHOLINO-4-PHENYLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2009-05-27 | — | — | EP | claimed |
| WO-2008032086-A1 | 2-BENZIMIDAZOLYL-6-MORPHOLINO-4-PHENYLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |