Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | GBA1 | P04062 | 3/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3987968 | 0.89 | JAK2 (0.51) | JAK2JAK3GBA1AURKAAURKB | |
| SCHEMBL3987459 | 0.87 | JAK2 (0.41) | JAK2JAK3AURKAAURKBMAPT | |
| SCHEMBL3987596 | 0.86 | MOK (0.38) | AURKAAURKBMAPTKDM4EHSD17B10 | |
| SCHEMBL3992722 | 0.84 | MOK (0.43) | MAPTMTORPIK3CAMOK | |
| SCHEMBL3988815 | 0.83 | MOK (0.42) | JAK2JAK3MAPTALDH1A1KDM4E | |
| SCHEMBL3988357 | 0.83 | AKT1 (0.43) | JAK2JAK3MAPTKDM4EHSD17B10 | |
| SCHEMBL3990070 | 0.81 | JAK2 (0.41) | JAK2JAK3MAPTHSD17B10MTOR | |
| SCHEMBL3984546 | 0.80 | PIK3CD (0.39) | JAK2JAK3MAPTALDH1A1MTOR | |
| SCHEMBL3984371 | 0.78 | MTOR (0.46) | JAK2MAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL3992366 | 0.77 | PKM (0.42) | MAPTALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061784-A1 | 2-BENZIMIDAZOLYL-6-MORPHOLINO-4-PHENYLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2009-05-27 | — | — | EP | claimed |
| WO-2008032086-A1 | 2-BENZIMIDAZOLYL-6-MORPHOLINO-4-PHENYLPYRIMIDINE DERIVATIVES AS PI3K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | claimed |