Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.31 |
| ▸ | TUBB | P07437 | 4/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.31 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.31 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.31 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.31 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.31 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.31 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.31 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.31 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.31 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.31 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.31 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL618660 | 0.92 | TUBB4A (0.34) | ADORA3ADORA2BTUBB4ATUBBTUBA3C | |
| Isothiazole SCHEMBL3980042 | 0.88 | INPPL1 (0.35) | ADORA3ADORA2BTUBB4ATUBBTUBA3C | |
| SCHEMBL10189249 | 0.86 | AR (0.31) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| Isothiazole SCHEMBL3987853 | 0.84 | TUBB4A (0.34) | ADORA3ADORA2BTUBB4ATUBBTUBA3C | |
| SCHEMBL615927 | 0.81 | TUBB4A (0.43) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL617193 | 0.80 | TUBB4A (0.42) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL616195 | 0.79 | INPPL1 (0.43) | ADORA3ADORA2BTUBB4ATUBBTUBA3C | |
| Isothiazole SCHEMBL3985152 | 0.78 | NEK2 (0.38) | ADORA3ADORA2BTUBB4ATUBBTUBA3C | |
| SCHEMBL617607 | 0.77 | MAPT (0.36) | ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| Isothiazole SCHEMBL3982389 | 0.77 | TUBB4A (0.36) | ADORA3ADORA2BTUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059250-A2 | COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS | Synta Pharmaceuticals Corporation (US) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008033449-A2 | COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS | SYNTA PHARMACEUTICALS CORP. (US) | 2008-03-20 | — | — | WO | disclosed |