Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.58 |
| ▸ | BCL2 | P10415 | 4/20 | 0.52 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5113101 | 0.99 | HTR7 (0.57) | HTR7BCL2BAK1HRH3LMNA | |
| SCHEMBL7130632 | 0.87 | HTR7 (0.57) | HTR7BCL2BAK1HRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9182345 | 0.87 | HTR7 (0.57) | HTR7BCL2BAK1HRH3LMNA | |
| SCHEMBL1446951 | 0.87 | HTR7 (0.57) | HTR7BCL2BAK1HRH3LMNA | |
| SCHEMBL2194377 | 0.87 | HTR7 (0.63) | HTR7BCL2BAK1HRH3LMNA | |
| SCHEMBL1138135 | 0.87 | HTR7 (0.60) | HTR7BCL2BAK1HRH3LMNA | |
| Hydrochloric Acid SCHEMBL9860099 | 0.86 | HTR7 (0.56) | HTR7BCL2BAK1HRH3LMNA | |
| SCHEMBL2193479 | 0.86 | HTR7 (0.56) | HTR7BCL2BAK1HRH3LMNA | |
| Hydrochloric Acid SCHEMBL9859525 | 0.85 | HTR7 (0.62) | HTR7BCL2BAK1HRH3LMNA | |
| SCHEMBL2116073 | 0.85 | HTR7 (0.53) | HTR7BCL2BAK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060258684-A1 | 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]acetic acid monohydrochloride as anti-allergenic compound and process for its production | WOCKHARDT LIMITED (IN) | 2006-11-16 | — | — | US | claimed |
| WO-2009062036-A2 | PROCESSES FOR PREPARING LEVOCETIRIZINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | DR. REDDY'S LABORATORIES LTD. (IN) | 2009-05-14 | — | — | WO | disclosed |
| US-20060258684-A1 | 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]acetic acid monohydrochloride as anti-allergenic compound and process for its production | WOCKHARDT LIMITED (IN) | 2006-11-16 | — | — | US | disclosed |
| CN-1692105-A | Cetirizine dihydrochloride polymorph and preparation method thereof | REDDY LAB CO LTD (IN) | 2005-11-02 | — | — | CN | disclosed |
| EP-1233955-B1 | PROCESS FOR PREPARING PIPERAZINE-SUBSTITUTED ALIPHATIC CARBOXYLATES | CAMBREX CHARLES CITY INC (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20040186112-A1 | Polymorphic forms of dihydrochloride salts of cetirizine and processes for preparation thereof | DR. REDDY'S LABORATORIES LIMITED | 2004-09-23 | — | — | US | disclosed |
| WO-2004050647-A2 | POLYMORPHIC FORMS OF DIHYDROCHLORIDE SALTS OF CETIRIZINE AND PROCESSES FOR PREPARATION THEREOF | DR. REDDY'S LABORATORIES LIMITED (IN) | 2004-06-17 | — | — | WO | disclosed |
| EP-1157016-B1 | A PROCESS FOR THE PREPARATION OF 2- 2- 4-(DIPHENYLMETHYL)-1-PIPERAZINYL]ETHOXY ACETIC ACID COMPOUNDS OR SALTS THEREOF | GEA FARMACEUTISK FABRIK AS (DK) | 2003-10-08 | — | — | EP | disclosed |
| EP-0927173-B1 | SUBSTITUTED [2-(1-PIPERAZINYL)ETHOXY]METHYL | UCB SA (BE) | 2002-06-12 | — | — | EP | disclosed |
| US-6265579-B1 | TREATING SOLUTION COMPRISING PIPERAZINE-SUBSTITUTED ETHANOL AND LEAVING GROUP-SUBSTITUTED ALIPHATIC ESTER WITH BASE IN PRESENCE OF PHASE TRANSFER CATALYST TO FORM CORRESPONDING ALIPHATIC CARBOXYLATE, HYDROLYZING WITH ACID | SALSBURY CHEMICALS, INC. | 2001-07-24 | — | — | US | disclosed |
| US-6255487-B1 | PREPARING 2-(2-(4-((4-CHLOROPHENYL)PHENYLMETHYL)-1-PIPER-AZINYL)ETHOXY)ACETIC ACID VIA REACTING SUBSTITUTED (2-((1-PIPERAZINYL)ETHOXY)METHYL COMPOUND WITH A DIPHENYLMETHYL HALIDE, THEN HYDROLYZING IN ALCOHOLIC MEDIUM WITH ACID/BASE | UCB, S.A. (BE) | 2001-07-03 | — | — | US | disclosed |
| US-6140501-A | CHEMICAL INTERMEDIATES | UCB, S.A. (BE) | 2000-10-31 | — | — | US | disclosed |
| EP-0801064-A1 | Process for the preparation of 2-(2-(4((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-acetic acid and their salts | U C B, S.A. (BE) | 1997-10-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258684-A1 | 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]acetic acid monohydrochloride as anti-allergenic compound and process for its production | CMA1, HRH2, HRH1 | HTR7 1413/4885BCL2 969/4885BAK1 466/4885 |
| US-20040186112-A1 | Polymorphic forms of dihydrochloride salts of cetirizine and processes for preparation thereof | HRH1, HRH4, HRH2 | HTR7 318/4885BCL2 4728/4885BAK1 4810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.