Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 16/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3923032 | 0.88 | ADRB2 (0.47) | ADRB2ADRB1TSHRLMNACYP3A4 | |
| SCHEMBL3913912 | 0.87 | ADRB2 (0.47) | ADRB2ADRB1TSHRLMNACYP3A4 | |
| SCHEMBL3913917 | 0.87 | ADRB2 (0.49) | ADRB2ADRB1TSHRLMNACYP3A4 | |
| SCHEMBL3918574 | 0.86 | ADRB2 (0.46) | ADRB2ADRB1TSHRLMNACYP3A4 | |
| SCHEMBL3913331 | 0.86 | ADRB2 (0.47) | ADRB2ADRB1TSHRLMNACYP3A4 | |
| SCHEMBL3992464 | 0.86 | ADRB2 (0.49) | ADRB2ADRB1TSHRLMNACYP3A4 | |
| SCHEMBL3915206 | 0.83 | ADRB2 (0.43) | ADRB2ADRB1ALDH1A1 | |
| SCHEMBL3915484 | 0.83 | ADRB2 (0.45) | ADRB2ADRB1TSHRLMNACYP3A4 | |
| SCHEMBL3912467 | 0.82 | ADRB2 (0.47) | ADRB2ADRB1TSHRLMNACYP3A4 | |
| SCHEMBL3987796 | 0.82 | ADRB2 (0.47) | ADRB2ADRB1TSHRLMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730141-B1 | COMPOUNDS FOR THE TREATMENT OF DISEASES | PFIZER LTD (GB) | 2009-05-27 | — | — | EP | claimed |