Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273972 | 0.86 | SRD5A2 (0.52) | HTTSRD5A2MAPK1HPGDCES2 | |
| SCHEMBL7264522 | 0.85 | HPGD (0.57) | HTTSRD5A2MAPK1HPGDCES2 | |
| SCHEMBL9416106 | 0.81 | SRD5A2 (0.50) | HTTSRD5A2MAPK1HPGDCES2 | |
| SCHEMBL27676963 | 0.79 | SRD5A2 (0.57) | HTTSRD5A2MAPK1HPGDCES2 | |
| SCHEMBL7264062 | 0.76 | HPGD (0.49) | HTTSRD5A2MAPK1HPGDCES2 | |
| SCHEMBL6234574 | 0.76 | MAPK1 (0.50) | HTTSRD5A2MAPK1HPGDCES2 | |
| SCHEMBL3983908 | 0.76 | MEN1 (0.50) | HTTMAPK1TDP1KMT2AMEN1 | |
| SCHEMBL10904964 | 0.76 | CYP3A4 (0.39) | HTTCES2CES1KMT2AMAPT | |
| SCHEMBL4747566 | 0.76 | SRD5A2 (0.64) | HTTSRD5A2MAPK1HPGDCES2 | |
| SCHEMBL11494893 | 0.75 | MAPK1 (0.48) | HTTSRD5A2MAPK1HPGDCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009060209-A1 | 6,6-FUSED BICYCLIC AROMATIC COMPOUNDS AND THEIR THERAPEUTI USE | ARGENTA DISCOVERY LIMITED (GB) | 2009-05-14 | — | — | WO | disclosed |