SCHEMBL39903

SCHEMBL39903

Nc1ccn([C@@H]2O[C@H](COP(=O)(O)O)[C@@H](OP(=O)(O)O)[C@H]2O)c(=O)n1

nearest known ligand 0.71

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
P2RY2 P41231 5/20 0.58
LMNA P02545 1/20 0.57
THRB P10828 1/20 0.57
MTOR P42345 1/20 0.57
MDM2 Q00987 1/20 0.57
NCOA1 Q15788 1/20 0.57
NCOA3 Q9Y6Q9 1/20 0.57
TSHR P16473 1/20 0.55
GLA P06280 1/20 0.55
ST6GAL1 P15907 6/20 0.53
P2RY6 Q15077 3/20 0.52
POLB P06746 1/20 0.52
P2RY4 P51582 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Choline SCHEMBL8755393 0.92 TSHR (0.57) P2RY2LMNATHRBMTORMDM2
SCHEMBL15954684 0.92 LMNA (0.57) P2RY2LMNATHRBMTORMDM2
SCHEMBL3608348 0.92 LMNA (0.69) P2RY2LMNATHRBMTORMDM2
SCHEMBL18151989 0.92 LMNA (0.69) P2RY2LMNATHRBMTORMDM2
SCHEMBL29712784 0.92 P2RY2 (0.52) P2RY2LMNATHRBMTORMDM2
SCHEMBL2212574 0.92 LMNA (0.69) P2RY2LMNATHRBMTORMDM2
SCHEMBL10177274 0.92 LMNA (0.69) P2RY2LMNATHRBMTORMDM2
SCHEMBL11617377 0.92 LMNA (0.69) P2RY2LMNATHRBMTORMDM2
SCHEMBL4735554 0.92 LMNA (0.69) P2RY2LMNATHRBMTORMDM2
SCHEMBL79966 0.92 LMNA (0.69) P2RY2LMNATHRBMTORMDM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024239431-A1 METHOD FOR PHOSPHORYLATION OF NUCLEIC ACID AT 3' END AND LIBRARY CONSTRUCTION 深圳华大智造科技股份有限公司 2024-11-28 WO claimed
CN-101705270-A Method for synthesizing deoxycytidine triphosphate through biotechnology JIANGSU HUARONG BIOLOG TECHNOL 2010-05-12 CN claimed
US-20250304929-A1 Enzyme Phosphorylating 2' Hydroxyl Group of RNA THE UNIVERSITY OF TOKYO (JP) 2025-10-02 US disclosed
WO-2025059367-A1 TREX-1 AUGMENTATION TO ATTENUATE GENOTOXIC STRESS AND EXERT CARDIOPROTECTION CEDARS-SINAI MEDICAL CENTER (US) 2025-03-20 WO disclosed
US-20250041324-A1 CYCLIC DINUCLEOTIDES AS AGONISTS OF STIMULATOR OF INTERFERON GENE DEPENDENT SIGNALLING BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2025-02-06 US disclosed
WO-2024239431-A1 METHOD FOR PHOSPHORYLATION OF NUCLEIC ACID AT 3' END AND LIBRARY CONSTRUCTION 深圳华大智造科技股份有限公司 2024-11-28 WO disclosed
US-12037579-B2 Synthetic RNA binding polypeptides THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2024-07-16 US disclosed
US-12036231-B2 Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-07-16 US disclosed
WO-2023195544-A1 ENZYME PHOSPHORYLATING 2'-HYDROXYL GROUP OF RNA 国立大学法人東京大学 2023-10-12 WO disclosed
WO-2023154848-A1 COMPOSITIONS AND METHODS FOR MODULATING NUCLEAR ENRICHED ABUNDANT TRANSCRIPT 1 TO TREAT COGNITIVE IMPAIRMENT MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) 2023-08-17 WO disclosed
EP-4139043-A1 METHODS FOR DIRECT SEQUENCING OF RNA New York Institute of Technology (US) 2023-03-01 EP disclosed
WO-1995032283-A1 SEQUENCE-SPECIFIC ENDONUCLEASES, AND PREPARATION AND USE OF SAME INDIANA UNIVERSITY FOUNDATION (US) 1995-11-30 WO disclosed
US-5397698-A Producing multiple copies of primary polynucleotide sequence; cleaving into fragments, dissociation and hybridizing SYNTEX (U.S.A.) INC. (US) 1995-03-14 US disclosed
EP-0357336-B1 Method for detection of specific nucleic acid sequences SYNTEX INC (US) 1994-10-05 EP disclosed
US-5273879-A Kits containing a single-stranded DNA oligomer bonded at its 3' end to a single-stranded polynucleotide binding sequence complementary to a target sequence; templates; restrictive sites; hybridization SYNTEX (U.S.A.) INC. (US) 1993-12-28 US disclosed
EP-0300796-B1 Amplification method for polynucleotide assays SYNTEX INC (US) 1993-10-20 EP disclosed
US-5185243-A Hybridizing two nucleotide sequences with a target nucleotide, covalently attaching two nucleotide sequences and determining the presence of covalently attached nucleotide sequences SYNTEX (U.S.A.) INC. (US) 1993-02-09 US disclosed
US-4994368-A Forming extension of hybridized polynucleotide sequence, cleaving, dissociating fragments, hybridizing fragments SYNTEX (U.S.A.) INC. (US) 1991-02-19 US disclosed
EP-0357336-A2 Method for detection of specific nucleic acid sequences SYNTEX (U.S.A.) INC. (US) 1990-03-07 EP disclosed
EP-0300796-A2 Amplification method for polynucleotide assays SYNTEX (U.S.A.) INC. (US) 1989-01-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12036231-B2 Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling STING1, IRF3, CGAS P2RY2 229/4885LMNA 4166/4885THRB 2070/4885
US-20250041324-A1 CYCLIC DINUCLEOTIDES AS AGONISTS OF STIMULATOR OF INTERFERON GENE DEPENDENT SIGNALLING STING1, IRF3, CGAS P2RY2 229/4885LMNA 4166/4885THRB 2070/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.