Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3990724 | 0.90 | MAPT (0.41) | SLC6A3SLC6A2CYP2D6MAPTMAPK1 | |
| SCHEMBL3993782 | 0.89 | KIT (0.44) | SLC6A3PTGDR2PPARGPPARAHRH1 | |
| SCHEMBL3210586 | 0.83 | ESR2 (0.48) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL3989283 | 0.78 | KIT (0.46) | MAPTPTGDR2PPARGPPARAHRH1 | |
| SCHEMBL3986658 | 0.75 | HTT (0.41) | SLC6A3SLC6A2CYP2D6MAPTMAPK1 | |
| SCHEMBL3184176 | 0.72 | ESR2 (0.47) | SLC6A3SLC6A2MAPTMAPK1HTT | |
| SCHEMBL13484596 | 0.72 | SLC6A3 (0.40) | SLC6A3SLC6A2MAPTMAPK1HTT | |
| SCHEMBL3199018 | 0.71 | ESR2 (0.48) | MAPTHTT | |
| SCHEMBL17485170 | 0.69 | SLC6A3 (0.55) | SLC6A3SLC6A2MAPTMAPK1HTT | |
| SCHEMBL3981548 | 0.68 | PTGDR2 (0.50) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064186-A1 | AZABICYCLIC COMPOUNDS AS INHIBITORS OF MONOAMINES REUPTAKE | Glaxo Group Limited (GB) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008031772-A1 | AZABICYCLIC COMPOUNDS AS INHIBITORS OF MONOAMINES REUPTAKE | GLAXO GROUP LIMITED (GB) | 2008-03-20 | — | — | WO | disclosed |