Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | ACMSD | Q8TDX5 | 8/20 | 0.67 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.67 |
| ▸ | DHFR | P00374 | 2/20 | 0.67 |
| ▸ | HNF4A | P41235 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 2/20 | 0.63 |
| ▸ | CA2 | P00918 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | TTR | P02766 | 1/20 | 0.63 |
| ▸ | ALB | P02768 | 1/20 | 0.63 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2512415 | 0.91 | ACMSD (0.65) | KDM4ELMNAHSD17B10ACMSDMCL1 | |
| SCHEMBL28683577 | 0.89 | KDM4E (0.68) | KDM4ELMNAHSD17B10ACMSDMCL1 | |
| SCHEMBL2771723 | 0.88 | ACMSD (0.83) | KDM4EHSD17B10ACMSDMCL1DHFR | |
| SCHEMBL29904854 | 0.88 | ACMSD (0.83) | KDM4EHSD17B10ACMSDMCL1DHFR | |
| Methane SCHEMBL28165586 | 0.86 | ACMSD (0.80) | KDM4EHSD17B10ACMSDMCL1DHFR | |
| SCHEMBL18224311 | 0.86 | ACMSD (0.88) | ACMSDMCL1DHFRHNF4ACA1 | |
| SCHEMBL22206257 | 0.86 | ACMSD (0.80) | KDM4EHSD17B10ACMSDMCL1DHFR | |
| SCHEMBL29374831 | 0.86 | ACMSD (0.88) | ACMSDMCL1DHFRHNF4ACA1 | |
| SCHEMBL330405 | 0.85 | ACMSD (0.72) | KDM4ELMNAHSD17B10ACMSDMCL1 | |
| SCHEMBL411333 | 0.83 | ACMSD (0.65) | KDM4ELMNAHSD17B10ACMSDMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544699-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2009-06-09 | — | — | US | disclosed |
| US-20050059705-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | VTVX HOLDINGS I LLC | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059705-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | TFPI, F3, F2 | KDM4E 1332/4885LMNA 575/4885HSD17B10 933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.