Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of P-Nitrophenylphosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BCL9 | O00512 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Nitrophenylphosphate SCHEMBL3992992 | 0.90 | CA1 (0.55) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL3992985 | 0.89 | CA1 (0.69) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL168768 | 0.82 | CA1 (0.69) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL844914 | 0.80 | CA1 (0.67) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL11103558 | 0.80 | CA1 (0.67) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL11322617 | 0.80 | CA1 (0.67) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL30776755 | 0.80 | CA1 (0.67) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL11322610 | 0.80 | CA1 (0.67) | CA1CA2CES2CES1BCHE | |
| P-Nitrophenylphosphate SCHEMBL11104501 | 0.80 | CA1 (0.67) | CA1CA2CES2CES1BCHE | |
| Choline SCHEMBL8662957 | 0.79 | BCL9 (0.51) | ALDH1A1MAPK1CYP3A4HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102712671-B | Phospholipase, the nucleic acid encoding it and preparation and their method of use | 帝斯曼知识产权资产管理有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-102575243-B | Oil degumming methods | BUNGE OILS, INC. (US) | 2016-02-03 | — | — | CN | disclosed |
| CN-102712671-A | Phospholipases, nucleic acids encoding them and methods for making and using them | VERENIUM CORP | 2012-10-03 | — | — | CN | disclosed |
| CN-102575243-A | Oil degumming methods | BUNGE OILS INC | 2012-07-11 | — | — | CN | disclosed |
| EP-1753454-B1 | VACCINE FOR PERIODONTAL DISEASE | PFIZER PROD INC (US) | 2009-05-27 | — | — | EP | disclosed |
| EP-1753454-A1 | VACCINE FOR PERIODONTAL DISEASE | Pfizer Products Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005112993-A1 | VACCINE FOR PERIODONTAL DISEASE | PFIZER PRODUCTS INC. (US) | 2005-12-01 | — | — | WO | disclosed |