Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of P-Nitrophenylphosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 4/20 | 0.69 |
| ▸ | CA2 known ✓ | P00918 | 4/20 | 0.69 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.58 |
| ▸ | CES2 | O00748 | 1/20 | 0.69 |
| ▸ | CES1 | P23141 | 1/20 | 0.69 |
| ▸ | ACHE | P22303 | 2/20 | 0.59 |
| ▸ | BCHE | P06276 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Nitrophenylphosphate SCHEMBL844914 | 0.98 | CA1 (0.67) | CA1CA2CES2CES1ACHE | |
| P-Nitrophenylphosphate SCHEMBL30776755 | 0.98 | CA1 (0.67) | CA1CA2CES2CES1ACHE | |
| P-Nitrophenylphosphate SCHEMBL11104501 | 0.98 | CA1 (0.67) | CA1CA2CES2CES1ACHE | |
| P-Nitrophenylphosphate SCHEMBL11103558 | 0.98 | CA1 (0.67) | CA1CA2CES2CES1ACHE | |
| P-Nitrophenylphosphate SCHEMBL11322617 | 0.98 | CA1 (0.67) | CA1CA2CES2CES1ACHE | |
| P-Nitrophenylphosphate SCHEMBL11322610 | 0.98 | CA1 (0.67) | CA1CA2CES2CES1ACHE | |
| SCHEMBL4609079 | 0.90 | CA1 (0.67) | CA1CA2CES2CES1ACHE | |
| P-Nitrophenylphosphate SCHEMBL29163719 | 0.87 | CA1 (0.54) | CA1CA2CES2CES1ACHE | |
| P-Nitrophenylphosphate SCHEMBL6681723 | 0.86 | CA1 (0.73) | CA1CA2CES2CES1ACHE | |
| SCHEMBL11588707 | 0.86 | CA1 (0.67) | CA1CA2CES2CES1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5200 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026085618-A1 | METHOD OF IMMOBILIZING CAPTURE PROBES TO SOLID PHASES FOR TARGET SUBSTANCE DETECTION | YYZ PHARMATECH INC. (CA) | 2026-04-30 | — | — | WO | claimed |
| EP-3464573-B1 | METAL IMPACT ON MANUFACTURING OF ALKALINE PHOSPHATASES | ALEXION PHARMA INC (US) | 2026-03-04 | — | — | EP | claimed |
| US-12545945-B2 | Methods for detection of rare subpopulations of cells and highly purified composition of cells | ASTELLAS INSTITUTE FOR REGENERATIVE MEDICINE (US) | 2026-02-10 | — | — | US | claimed |
| EP-4677362-A1 | ENZYME LINKED IMMUNOASSAY WITH DIFFUSION RATE LIMITING MEDIUM | Elleon Biotech Limited (HK) | 2026-01-14 | — | — | EP | claimed |
| EP-4677353-A1 | SYSTEM FOR LABEL-FREE ELECTROCHEMICAL SENSING | President And Fellows Of Harvard College (US) | 2026-01-14 | — | — | EP | claimed |
| US-20250354204-A1 | AUTOMATED RNA DETECTION USING LABELED 2'-O-METHYL RNA OLIGONUCLEOTIDE PROBES AND SIGNAL AMPLIFICATION SYSTEMS | VENTANA MED SYST INC (US) | 2025-11-20 | — | — | US | claimed |
| EP-4637776-A1 | USE OF DUPD1 INHIBITORS IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE AND METABOLIC DISORDERS | The Governing Council of the University of Toronto (CA) | 2025-10-29 | — | — | EP | claimed |
| US-20250326723-A1 | Development of an Enzyme-Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One-Pot Megamolecule Assembly | UNIV NORTHWESTERN (US) | 2025-10-23 | — | — | US | claimed |
| CN-120195244-A | Photoelectrochemical biosensor for detecting escherichia coli and preparation method thereof | 山东农业大学 | 2025-06-24 | — | — | CN | claimed |
| CN-114761806-B | Colorimetric detection of target materials based on hydrogel particles | 高丽大学校产学协力团 | 2025-05-09 | — | — | CN | claimed |
| US-20070020719-A1 | Selective culture medium for the isolation and/or detection of species in the streptococcus genus | DURAN VILA ANABEL | 2007-01-25 | — | — | US | claimed |
| EP-1600514-A2 | SELECTIVE CULTURE MEDIUM FOR THE ISOLATION AND/OR DETECTION OF SPECIES IN THE STREPTOCOCCUS GENUS | CENTRO NACIONAL DE BIOPREPARADOS (CU) | 2005-11-30 | — | — | EP | claimed |
| US-6299912-B1 | ANIMAL FEEDS | SHOWA DENKO KABUSHIKI KAISHA (JP) | 2001-10-09 | — | — | US | claimed |
| EP-1046345-A2 | Preparation for administration to animals and feeding method thereof | SHOWA DENKO KABUSHIKI KAISHA (JP) | 2000-10-25 | — | — | EP | claimed |
| US-5665802-A | REACTING POLYAMIC ACID WITH A DEHYDRATION-CYCLIZATION AGENT, A CATALYST AND AN ORGANIC PHOSPHORUS COMPOUND; EXCELLENT IN TENSILE STRENGTH AND FLEXIBILITY | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1997-09-09 | — | — | US | claimed |
| US-5500668-A | INK JET PRINTING | XEROX CORPORATION (US) | 1996-03-19 | — | — | US | claimed |
| EP-0647849-A2 | Detecting the presence of analytes in a sample | IGEN, INC. (US) | 1995-04-12 | — | — | EP | claimed |
| EP-0265519-A4 | ELECTROCHEMILUMINESCENT ASSAYS. | IGEN INC (US) | 1990-05-14 | — | — | EP | claimed |
| EP-0265519-A1 | ELECTROCHEMILUMINESCENT ASSAYS. | IGEN INC (US) | 1988-05-04 | — | — | EP | claimed |
| WO-1987006706-A1 | ELECTROCHEMILUMINESCENT ASSAYS | IGEN, INC. (US) | 1987-11-05 | — | — | WO | claimed |