Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719471 | 1.00 | ALDH1A1 (0.47) | ALDH1A1KMT2AHSD17B10HTTL3MBTL1 | |
| SCHEMBL1719407 | 0.99 | ALDH1A1 (0.45) | ALDH1A1KMT2AHSD17B10HTTL3MBTL1 | |
| SCHEMBL1719387 | 0.95 | ALDH1A1 (0.40) | ALDH1A1KMT2AHSD17B10HTTL3MBTL1 | |
| SCHEMBL1720086 | 0.90 | SMN1; SMN2 (0.40) | ALDH1A1KMT2AHSD17B10HTTTSHR | |
| SCHEMBL1719815 | 0.84 | ALDH1A1 (0.39) | ALDH1A1KMT2AHSD17B10TSHRKDM4E | |
| SCHEMBL1720297 | 0.81 | ALDH1A1 (0.34) | ALDH1A1L3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL1719384 | 0.79 | KMT2A (0.35) | ALDH1A1KMT2AKDM4EMEN1GAA | |
| SCHEMBL1719442 | 0.77 | MAPT (0.30) | KMT2AMAPT | |
| SCHEMBL1719852 | 0.76 | TSHR (0.35) | ALDH1A1KMT2AHTTL3MBTL1TSHR | |
| SCHEMBL6990452 | 0.76 | ALDH1A1 (0.49) | ALDH1A1KMT2AHSD17B10HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037928-A2 | METHODS FOR TREATING ATHEROSCLEROSIS | Amgen Inc. (US) | 2009-03-25 | — | — | EP | claimed |
| WO-2008002591-A2 | METHODS FOR TREATING ATHEROSCLEROSIS | AMGEN INC (US) | 2008-01-03 | — | — | WO | claimed |