Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 6/20 | 0.63 |
| ▸ | GUCY1B1 | Q02153 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | HPGD | P15428 | 7/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | MC4R | P32245 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2364934 | 0.85 | MEN1 (0.70) | GUCY1A1GUCY1B1KDM4EALDH1A1MAPT | |
| SCHEMBL1198425 | 0.84 | KDM4E (0.78) | KDM4EHPGDL3MBTL1ALDH1A1MAPT | |
| SCHEMBL18707080 | 0.84 | KEAP1 (0.78) | GUCY1A1GUCY1B1KDM4EHPGDL3MBTL1 | |
| SCHEMBL3037767 | 0.83 | GUCY1A1 (0.68) | GUCY1A1GUCY1B1KDM4EHPGDL3MBTL1 | |
| SCHEMBL4003597 | 0.83 | GUCY1A1 (0.61) | GUCY1A1GUCY1B1KDM4EHPGDL3MBTL1 | |
| SCHEMBL1782567 | 0.83 | GUCY1A1 (0.62) | GUCY1A1GUCY1B1KDM4EHPGDL3MBTL1 | |
| SCHEMBL18733849 | 0.83 | GUCY1A1 (0.61) | GUCY1A1GUCY1B1KDM4EHPGDL3MBTL1 | |
| SCHEMBL3041721 | 0.82 | GUCY1A1 (0.62) | GUCY1A1GUCY1B1KDM4EHPGDL3MBTL1 | |
| SCHEMBL1780792 | 0.82 | GUCY1A1 (0.64) | GUCY1A1GUCY1B1KDM4EHPGDL3MBTL1 | |
| SCHEMBL16556003 | 0.82 | GUCY1A1 (0.66) | GUCY1A1GUCY1B1KDM4EHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009068652-A1 | 2, 6-DISUBSTITUTED PYRIDINES AND 2, 4-DISUBSTITUTED PYRIMIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009068652-A1 | 2, 6-DISUBSTITUTED PYRIDINES AND 2, 4-DISUBSTITUTED PYRIMIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |