Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | LYN | P07948 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3993667 | 0.81 | CSNK1A1 (0.34) | EGFRHTTPRKCQPRKCDALDH1A1 | |
| SCHEMBL4947538 | 0.81 | EGFR (0.32) | EGFRERBB2TTRALBPRKCQ | |
| SCHEMBL31097392 | 0.74 | EGFR (0.33) | EGFRERBB2HTT | |
| SCHEMBL7484421 | 0.71 | KDM4E (0.37) | EGFRMEN1KMT2AHTTKDM4E | |
| SCHEMBL31674353 | 0.70 | AURKA (0.37) | HTTPRKCQMAP2K1KDM4EALDH1A1 | |
| SCHEMBL3998036 | 0.70 | AURKA (0.37) | HTTPRKCQMAP2K1KDM4EALDH1A1 | |
| SCHEMBL13976998 | 0.68 | EGFR (0.46) | EGFRERBB2HTTMAPT | |
| SCHEMBL29775134 | 0.68 | EGFR (0.46) | EGFRERBB2HTTMAPT | |
| SCHEMBL14373172 | 0.68 | LRRK2 (0.34) | EGFRERBB2HTT | |
| SCHEMBL3088035 | 0.68 | ALDH1A1 (0.37) | HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101573364-A | Process for the preparation of 4-hydroxythieno [2, 3-b ] pyridine-5-carbonitriles | WYETH CORP (US) | 2009-11-04 | — | — | CN | disclosed |
| EP-2066675-A1 | PROCESS FOR THE PREPARATION OF 4-HYDROXYTHIENO[2,3-B]PYRIDINE-5-CARBONITRILES | Wyeth (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008039414-A1 | PROCESS FOR THE PREPARATION OF 4-HYDROXYTHIENO[2,3-B]PYRIDINE-5-CARBONITRILES | WYETH (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20080076926-A1 | Process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles | WYETH | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076926-A1 | Process for the preparation of 4-hydroxythieno[2,3-b]pyridine-5-carbonitriles | MAP4K2, MAP4K1, MAP4K3 | EGFR 1467/4885ERBB2 320/4885MEN1 1879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.