Clobetasol

Clobetasol

SCHEMBL3996

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CCl

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 8/20 0.85
CYP3A4 P08684 7/20 0.85
HIF1A Q16665 7/20 0.85
HSD17B10 Q99714 3/20 0.85
NFKB1 P19838 3/20 0.85
PGR P06401 3/20 0.85
TSHR P16473 2/20 0.85
AR P10275 2/20 0.85
PMP22 Q01453 2/20 0.85
MEN1 O00255 1/20 0.85
CYP2D6 P10635 1/20 0.85
KMT2A Q03164 1/20 0.85
APEX1 P27695 1/20 0.85
NPSR1 Q6W5P4 1/20 0.85
IKBKB O14920 1/20 0.85
CHUK O15111 1/20 0.85
ADRB2 P07550 1/20 0.85
NR3C2 P08235 1/20 0.85
PLA2G2A P14555 1/20 0.85
NFKB2 Q00653 1/20 0.85

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Clobetasol SCHEMBL1651129 1.00 NR3C1 (0.85) NR3C1CYP3A4HIF1AHSD17B10NFKB1
Clobetasol SCHEMBL8602501 1.00 NR3C1 (0.85) NR3C1CYP3A4HIF1AHSD17B10NFKB1
Clobetasol SCHEMBL7616575 1.00 NR3C1 (0.85) NR3C1CYP3A4HIF1AHSD17B10NFKB1
Clobetasol SCHEMBL13046611 1.00 NR3C1 (0.85) NR3C1CYP3A4HIF1AHSD17B10NFKB1
Clobetasol SCHEMBL5034388 1.00 NR3C1 (0.85) NR3C1CYP3A4HIF1AHSD17B10NFKB1
Clobetasol SCHEMBL30915305 1.00 NR3C1 (0.85) NR3C1CYP3A4HIF1AHSD17B10NFKB1
Clobetasol SCHEMBL19327129 1.00 NR3C1 (0.85) NR3C1CYP3A4HIF1AHSD17B10NFKB1
Clobetasol SCHEMBL5034390 1.00 NR3C1 (0.85) NR3C1CYP3A4HIF1AHSD17B10NFKB1
Clobetasol SCHEMBL28167282 0.99 NR3C1 (0.83) NR3C1CYP3A4HIF1AHSD17B10NFKB1
Dexamethasone SCHEMBL20770143 0.97 HIF1A (0.92) NR3C1CYP3A4HIF1AHSD17B10NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 21455 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260137657-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS SPARROW PHARMACEUTICALS INC (US) 2026-05-21 US claimed
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 US claimed
US-20260137656-A1 METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS SPARROW PHARMACEUTICALS INC (US) 2026-05-21 US claimed
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 WO claimed
US-20260130899-A1 METHOD OF TREATMENT FOR PREVENTION OF GLUCOCORTICOID TOXICITY AND/OR ENHANCEMENT OF MUSCLE REGENERATION VIA NEUTROPHIL ELASTASE INHIBITION THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2026-05-14 US claimed
EP-4741421-A1 FAB-ARM EXCHANGE-PREVENTING FC VARIANTS FROM WHICH EFFECTOR FUNCTIONS ARE REMOVED Korea University Research and Business Foundation (KR) 2026-05-13 EP claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
EP-3222270-B1 COMPOSITIONS FOR MUCOSAL ADHESION AND USES THEREOF BIONANOPLUS S L (ES) 2026-04-29 EP claimed
US-20260103492-A1 CYCLOSPORINE COMPOSITIONS AND METHODS OF USE BACAINN BIOTHERAPEUTICS, LTD. (KY) 2026-04-16 US claimed
US-12599556-B2 Ophthalmic compositions BIOTHERAVISION INC. (US) 2026-04-14 US claimed
US-4851521-A Esters of hyaluronic acid FIDIA, S.P.A. (IT) 1989-07-25 US claimed
EP-0265116-A2 Cross-linked esters of hyaluronic acid FIDIA S.p.A. (IT) 1988-04-27 EP claimed
CN-87104499-A Novel alginic acid esters 1988-04-06 CN claimed
EP-0251905-A2 Esters of alginic acid FIDIA S.p.A. (IT) 1988-01-07 EP claimed
EP-0241134-A1 Pharmaceutical mixture comprising nedocromil or a salt thereof in combination with a bronchodilator FISONS plc (GB) 1987-10-14 EP claimed
EP-0216453-A2 Esters of hyaluronic acid and their salts. FIDIA S.p.A. (IT) 1987-04-01 EP claimed
EP-0197718-A2 New medicaments for topical use FIDIA S.p.A. (IT) 1986-10-15 EP claimed
EP-0173478-A1 Treatment of skin disorders SCOTIA HOLDINGS PLC (GB) 1986-03-05 EP claimed
EP-0068553-B1 TOPICAL ANTIMICROBIAL ANTI-INFLAMMATORY COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 1985-11-21 EP claimed
US-4333927-A CORTICOSTEROID, PHOSPHATIDE, BUTYLHYDROXYANISOLE AND/OR BUTYLHYDROXYTOLUENE MITSUBISHI CHEMICAL INDUSTRIES, LTD. (JP) 1982-06-08 US claimed