Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | IL1B | P01584 | 2/20 | 0.40 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.40 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HBB | P68871 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1358007 | 0.83 | CRBN (0.58) | CRBNDDB1IKZF3BRD4MAPK1 | |
| SCHEMBL1426296 | 0.79 | CRBN (0.70) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL3744071 | 0.77 | CRBN (0.65) | CRBNDDB1TNFIL1BIKZF1 | |
| Hydrochloric Acid SCHEMBL3739220 | 0.76 | CRBN (0.63) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL3742152 | 0.71 | DDB1 (0.63) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL4456882 | 0.70 | CRBN (0.33) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL26964211 | 0.69 | SLC18A3 (0.38) | MAPK1SLC18A3LMNASLC6A2SLC6A4 | |
| SCHEMBL25297029 | 0.68 | CRBN (0.38) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL30496668 | 0.68 | CRBN (0.38) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL29878132 | 0.66 | CRBN (0.70) | CRBNDDB1TNFIL1BIKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1733726-B1 | Pharmaceutically active isoindoline derivatives | CELGENE CORP (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1733726-A1 | Pharmaceutically active isoindoline derivatives | Celgene Corporation (US) | 2006-12-20 | — | — | EP | disclosed |