Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3998206 | 0.95 | PARP1 (0.40) | PARP1NR3C2MMP8MMP13TRPV1 | |
| SCHEMBL4000695 | 0.94 | PARP1 (0.39) | PARP1NR3C2MMP8MMP13TRPV1 | |
| SCHEMBL3998191 | 0.89 | TRPV1 (0.36) | PARP1NR3C2MMP8MMP13TRPV1 | |
| SCHEMBL4000751 | 0.84 | TACR1 (0.36) | DRD2HTR1AHTR2A | |
| SCHEMBL4003970 | 0.83 | TACR1 (0.36) | — | |
| SCHEMBL4728919 | 0.80 | TACR1 (0.36) | DRD2DRD4 | |
| SCHEMBL4001725 | 0.80 | TACR1 (0.39) | — | |
| SCHEMBL4730592 | 0.78 | TACR1 (0.35) | — | |
| SCHEMBL3996200 | 0.78 | TACR1 (0.36) | — | |
| SCHEMBL3995308 | 0.77 | PIM1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076404-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2009-06-18 | — | — | WO | claimed |
| WO-2009076404-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2009-06-18 | — | — | WO | disclosed |