SCHEMBL3996935

SCHEMBL3996935

CN(Cc1nc2ccccc2n1CCCC1CCCCN1C(=O)O)C1CCCc2cccnc21

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 20/20 0.69
KCNH2 Q12809 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3990763 0.95 CXCR4 (0.66) CXCR4KCNH2
SCHEMBL4939479 0.90 CXCR4 (0.63) CXCR4KCNH2
SCHEMBL4932346 0.89 CXCR4 (0.75) CXCR4KCNH2
SCHEMBL4933459 0.86 CXCR4 (0.61) CXCR4KCNH2
SCHEMBL4938094 0.84 CXCR4 (0.72) CXCR4KCNH2
SCHEMBL3994033 0.84 CXCR4 (0.71) CXCR4KCNH2
SCHEMBL3993485 0.82 CXCR4 (0.73) CXCR4KCNH2
SCHEMBL4939469 0.82 CXCR4 (1.00) CXCR4KCNH2
SCHEMBL4938814 0.82 CXCR4 (0.83) CXCR4KCNH2
SCHEMBL4940042 0.82 CXCR4 (0.83) CXCR4KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1778231-A4 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORP (US) 2009-06-03 EP disclosed
EP-1778231-A1 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2007-05-02 EP disclosed
WO-2006020415-A1 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2006-02-23 WO disclosed