Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.71 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.71 |
| ▸ | AKT1 | P31749 | 11/20 | 0.64 |
| ▸ | MTOR | P42345 | 8/20 | 0.64 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1123992 | 0.84 | HTT (0.52) | PIK3CAAKT1MTORPIK3CB | |
| SCHEMBL1124039 | 0.84 | HTT (0.52) | PIK3CAAKT1MTORPIK3CB | |
| SCHEMBL10327890 | 0.84 | PIK3CA (1.00) | PIK3CAMAP3K12AKT1MTORPIK3R1 | |
| SCHEMBL4123039 | 0.82 | PIK3CA (0.50) | PIK3CAMAP3K12AKT1MTORPIK3R1 | |
| SCHEMBL10327659 | 0.81 | PIK3CA (0.92) | PIK3CAMAP3K12AKT1MTORPIK3R1 | |
| SCHEMBL4110708 | 0.80 | PIK3CA (0.69) | PIK3CAMAP3K12AKT1MTORPIK3R1 | |
| SCHEMBL13848122 | 0.80 | PIK3CA (0.72) | PIK3CAMAP3K12AKT1MTORPIK3R1 | |
| SCHEMBL3994777 | 0.79 | PIK3CA (0.72) | PIK3CAMAP3K12AKT1MTORPIK3R1 | |
| SCHEMBL21464318 | 0.79 | PIK3CA (1.00) | PIK3CAMAP3K12AKT1MTOR | |
| SCHEMBL29923262 | 0.79 | PIK3CA (1.00) | PIK3CAMAP3K12AKT1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | claimed |
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |