Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.69 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.69 |
| ▸ | AKT1 | P31749 | 10/20 | 0.66 |
| ▸ | MTOR | P42345 | 9/20 | 0.66 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.59 |
| ▸ | BRAF | P15056 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | GBA1 | P04062 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10327890 | 0.83 | PIK3CA (1.00) | PIK3CAMAP3K12AKT1MTORPIK3R1 | |
| SCHEMBL4107369 | 0.81 | PIK3CA (0.69) | PIK3CAMAP3K12AKT1MTORPIK3R1 | |
| SCHEMBL3994777 | 0.80 | PIK3CA (0.72) | PIK3CAMAP3K12AKT1MTORPIK3R1 | |
| SCHEMBL10327659 | 0.80 | PIK3CA (0.92) | PIK3CAMAP3K12AKT1MTORPIK3R1 | |
| SCHEMBL21464293 | 0.80 | PIK3CA (1.00) | PIK3CAMAP3K12AKT1MTOR | |
| SCHEMBL29922822 | 0.80 | PIK3CA (1.00) | PIK3CAMAP3K12AKT1MTOR | |
| SCHEMBL3997488 | 0.80 | PIK3CA (0.71) | PIK3CAMAP3K12AKT1MTORPIK3R1 | |
| SCHEMBL3995928 | 0.79 | GBA1 (0.60) | PIK3CAGBA1 | |
| SCHEMBL3993432 | 0.79 | PIK3CA (0.86) | PIK3CAMAP3K12AKT1MTORPIK3R1 | |
| SCHEMBL13848122 | 0.79 | PIK3CA (0.72) | PIK3CAMAP3K12AKT1MTORPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | claimed |
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | disclosed |