Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4002214 | 0.89 | SSTR5 (0.50) | SSTR5KDM4EALDH1A1NPSR1HRH1 | |
| SCHEMBL3998650 | 0.89 | SSTR5 (0.47) | SSTR5KDM4EALDH1A1HRH1HTR2B | |
| SCHEMBL3997523 | 0.86 | SSTR5 (0.45) | SSTR5KDM4EALDH1A1NPSR1HRH1 | |
| SCHEMBL4000512 | 0.85 | SSTR5 (0.46) | SSTR5KDM4EALDH1A1NPSR1HRH1 | |
| SCHEMBL3999527 | 0.81 | SSTR5 (0.40) | SSTR5KDM4EHRH1HTR2BKMT2A | |
| SCHEMBL4002555 | 0.79 | NPC1 (0.43) | SSTR5KDM4EALDH1A1HRH1HTR2B | |
| SCHEMBL4003510 | 0.79 | SSTR5 (0.47) | SSTR5NPSR1MAPK1HSD17B10 | |
| SCHEMBL1878140 | 0.78 | SSTR5 (0.51) | SSTR5HRH1HTR2B | |
| SCHEMBL4004390 | 0.78 | SSTR5 (0.47) | SSTR5KDM4EALDH1A1HRH1MAPK1 | |
| SCHEMBL4000428 | 0.77 | SSTR5 (0.56) | SSTR5KDM4EALDH1A1NPSR1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066658-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008031735-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | WO | disclosed |