Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 12/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4002214 | 0.89 | SSTR5 (0.50) | SSTR5HRH1HTR2BKMT2AKDM4E | |
| SCHEMBL3996567 | 0.86 | SSTR5 (0.46) | SSTR5HRH1HTR2BALDH1A1ABCB1 | |
| SCHEMBL4002555 | 0.85 | NPC1 (0.43) | SSTR5HRH1HTR2BKMT2AKDM4E | |
| SCHEMBL3993879 | 0.85 | SSTR5 (0.45) | SSTR5HRH1HTR2BKMT2AKDM4E | |
| SCHEMBL3996819 | 0.85 | SSTR5 (0.48) | SSTR5HRH1HTR2BKMT2AMEN1 | |
| SCHEMBL3997883 | 0.84 | SSTR5 (0.43) | SSTR5HRH1HTR2BALDH1A1ABCB1 | |
| SCHEMBL4002203 | 0.84 | SSTR5 (0.53) | SSTR5HRH1HTR2BKMT2AALDH1A1 | |
| SCHEMBL3997486 | 0.83 | SSTR5 (0.52) | SSTR5HRH1HTR2BKCNH2 | |
| SCHEMBL4002561 | 0.83 | DRD2 (0.45) | SSTR5HRH1HTR2BKMT2AMEN1 | |
| SCHEMBL4000512 | 0.81 | SSTR5 (0.46) | SSTR5HRH1HTR2BKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066658-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-06-10 | — | — | EP | claimed |
| WO-2008031735-A1 | PYRIDINE- AND QUINOLINE-PYRIMIDINE-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | WO | claimed |